[Plsgs] FW: You Are Invited-ORGINS Seminar by David Craik

[Garcia, Jennifer Jene - (jennyj)]

Prof. David Craik has made discoveries of new classes of proteins, generated new knowledge on their structure and function, and used this information to design and chemically re-engineer new classes of protein-based drug leads and agricultural pest control agents. In particular, his major achievements are:

                * the discovery of cyclotides, the largest known family of circular proteins. As well as a circular backbone, cyclotides contain a knotted arrangement of cross-linking disulfide bonds, making them remarkably stable. His discovery of these proteins was sparked in part from anecdotal reports of medicinal practices in Africa where women make a tea from the plant Oldenlandia affinis by boiling it in water and sipping it during labour to accelerate child birth. He determined the structure of the bioactive component of this medicinal tea and found that it had an unprecedented head-to-tail cyclic peptide backbone combined with a cystine knot.

                * the first structural and functional characterizations of prototypic circular proteins in higher organisms - Professor Craik was one of the first to recognize that other families of ribosomally synthesized cyclic peptides exist. As examples from bacteria and animals emerged, Professor Craik was at the forefront of their structural characterization, reporting the first structures of theta-defensins from animals and the threaded lasso peptide microcin J25 from bacteria, as well as new examples of cyclic peptides from plants.

                * the development of artificially cyclized peptide toxins as drug leads - he developed an orally active peptide that is 100 times more potent than the leading clinically used drug for neuropathic pain.



All Best Wishes
Minying Cai

Minying Cai Ph.D
Research Professor
Department of Chemistry & Biochemistry
Arizona Cancer Center
Bio 5 Institute
1306 E University Blvd
Tucson, AZ 85721
Email: mcai at email.arizona.edu<mailto:mcai at email.arizona.edu>
Tel: 520-6218617
________________________________
From: McKinley, Ashley D - (mckinleya) <mckinleya at arizona.edu<mailto:mckinleya at arizona.edu>>
Sent: Friday, October 21, 2022 10:20 AM
To: cbcfac at list.arizona.edu<mailto:cbcfac at list.arizona.edu> <cbcfac at list.arizona.edu<mailto:cbcfac at list.arizona.edu>>
Cc: Cai, Minying - (mcai) <mcai at arizona.edu<mailto:mcai at arizona.edu>>
Subject: You Are Invited-ORGINS Seminar by David Craik


Dear CBC Faculty,



You are invited to attend next week's ORGINS seminar on Monday, October 24, from 4:00-5:00 pm. The visiting speaker is Professor David Craik, Institute for Molecular Bioscience, The University of Queensland, Australia.



Seminar title: Discovery and applications of cyclotides

Host: Dr. Minying Cai



[cid:image003.png at 01D8E2FD.7F468180]



Respectfully,



[The University of Arizona block 'A' logo.]

Ashley D McKinley
Administrative Support Assistant II
Chemistry & Biochemistry - Sci
THE UNIVERSITY OF ARIZONA



Biological Sciences West, 368
PO Box 210088 | Tucson, AZ 85721
Office: 520-621-6354
mckinleya at arizona.edu<mailto:mckinleya at arizona.edu>

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