<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=us-ascii">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Tahoma;
panose-1:2 11 6 4 3 5 4 4 2 4;}
@font-face
{font-family:"Bell MT";
panose-1:2 2 5 3 6 3 5 2 3 3;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:#0563C1;
text-decoration:underline;}
p.contentpasted0, li.contentpasted0, div.contentpasted0
{mso-style-name:contentpasted0;
margin:0in;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
span.contentpasted01
{mso-style-name:contentpasted01;}
p.xmsonormal, li.xmsonormal, div.xmsonormal
{mso-style-name:x_msonormal;
margin:0in;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="EN-US" link="#0563C1" vlink="purple" style="word-wrap:break-word">
<div class="WordSection1">
<div>
<p class="contentpasted0"><b><span style="font-size:12.0pt;color:black">Prof. David Craik</span></b><span style="font-size:12.0pt;color:black"> has made discoveries of new classes of proteins, generated new knowledge on their structure and function, and used
this information to design and chemically re-engineer new classes of protein-based drug leads and agricultural pest control agents. In particular, his major achievements are:<o:p></o:p></span></p>
<div>
<p class="contentpasted0"><span class="contentpasted01"><span style="font-size:12.0pt;color:black">
</span></span><span style="font-size:12.0pt;color:black">• the discovery of cyclotides, the largest known family of circular proteins. As well as a circular backbone, cyclotides contain a knotted arrangement of cross-linking disulfide bonds, making them remarkably
stable. His discovery of these proteins was sparked in part from anecdotal reports of medicinal practices in Africa where women make a tea from the plant Oldenlandia affinis by boiling it in water and sipping it during labour to accelerate child birth. He
determined the structure of the bioactive component of this medicinal tea and found that it had an unprecedented head-to-tail cyclic peptide backbone combined with a cystine knot.<o:p></o:p></span></p>
</div>
<div>
<p class="contentpasted0"><span class="contentpasted01"><span style="font-size:12.0pt;color:black">
</span></span><span style="font-size:12.0pt;color:black">• the first structural and functional characterizations of prototypic circular proteins in higher organisms - Professor Craik was one of the first to recognize that other families of ribosomally synthesized cyclic
peptides exist. As examples from bacteria and animals emerged, Professor Craik was at the forefront of their structural characterization, reporting the first structures of theta-defensins from animals and the threaded lasso peptide microcin J25 from bacteria,
as well as new examples of cyclic peptides from plants.<o:p></o:p></span></p>
</div>
<div>
<p class="contentpasted0"><span class="contentpasted01"><span style="font-size:12.0pt;color:black">
</span></span><span style="font-size:12.0pt;color:black">• the development of artificially cyclized peptide toxins as drug leads – he developed an orally active peptide that is 100 times more potent than the leading clinically used drug for neuropathic pain.<o:p></o:p></span></p>
<p class="contentpasted0"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
<p class="contentpasted0"><span style="font-size:12.0pt;color:black">All Best Wishes<o:p></o:p></span></p>
</div>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black">Minying Cai<o:p></o:p></span></p>
</div>
<div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
</div>
<div id="Signature">
<div>
<div>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif">Minying Cai Ph.D<br>
Research Professor<br>
Department of Chemistry & Biochemistry <o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif">Arizona Cancer Center<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif">Bio 5 Institute<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif">1306 E University Blvd<br>
Tucson, AZ 85721<br>
Email: <a href="mailto:mcai@email.arizona.edu">mcai@email.arizona.edu</a><br>
Tel: 520-6218617<o:p></o:p></span></p>
</div>
</div>
</div>
</div>
<div class="MsoNormal" align="center" style="text-align:center">
<hr size="2" width="98%" align="center">
</div>
<div id="divRplyFwdMsg">
<p class="MsoNormal"><b><span style="color:black">From:</span></b><span style="color:black"> McKinley, Ashley D - (mckinleya) <<a href="mailto:mckinleya@arizona.edu">mckinleya@arizona.edu</a>><br>
<b>Sent:</b> Friday, October 21, 2022 10:20 AM<br>
<b>To:</b> <a href="mailto:cbcfac@list.arizona.edu">cbcfac@list.arizona.edu</a> <<a href="mailto:cbcfac@list.arizona.edu">cbcfac@list.arizona.edu</a>><br>
<b>Cc:</b> Cai, Minying - (mcai) <<a href="mailto:mcai@arizona.edu">mcai@arizona.edu</a>><br>
<b>Subject:</b> You Are Invited-ORGINS Seminar by David Craik</span> <o:p></o:p></p>
<div>
<p class="MsoNormal"> <o:p></o:p></p>
</div>
</div>
<div>
<div>
<p class="xmsonormal"><span style="font-size:14.0pt;font-family:"Bell MT",serif">Dear CBC Faculty,</span><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:14.0pt;font-family:"Bell MT",serif"> </span><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:14.0pt;font-family:"Bell MT",serif">You are invited to attend next week’s ORGINS seminar on Monday, October 24, from 4:00-5:00 pm. The visiting speaker is Professor David Craik, Institute for Molecular Bioscience,
The University of Queensland, Australia. </span><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:14.0pt;font-family:"Bell MT",serif"> </span><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:14.0pt;font-family:"Bell MT",serif">Seminar title:
<b>Discovery and applications of cyclotides</b></span><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:14.0pt;font-family:"Bell MT",serif">Host: Dr. Minying Cai</span><o:p></o:p></p>
<p class="xmsonormal"> <o:p></o:p></p>
<p class="xmsonormal"><img border="0" width="604" height="779" style="width:6.2916in;height:8.1145in" id="x_Picture_x0020_5" src="cid:image003.png@01D8E2FD.7F468180"><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:14.0pt;font-family:"Bell MT",serif"> </span><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:14.0pt;font-family:"Bell MT",serif">Respectfully,</span><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:12.0pt;font-family:"Bell MT",serif"> </span><o:p></o:p></p>
<table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0">
<tbody>
<tr>
<td valign="top" style="padding:0in 0in 0in 0in">
<p class="xmsonormal"><img border="0" width="120" height="96" style="width:1.25in;height:1.0in" id="x_Picture_x0020_9" src="cid:image001.png@01D8E2FC.11044C80" alt="The University of Arizona block 'A' logo."><o:p></o:p></p>
</td>
<td width="500" valign="top" style="width:375.0pt;padding:0in 0in 0in 0in">
<p class="xmsonormal"><b><span style="font-size:14.0pt;color:#0C234B">Ashley D McKinley</span></b><span style="font-size:10.0pt;color:#495057"><br>
Administrative Support Assistant II<br>
Chemistry & Biochemistry - Sci<br>
THE UNIVERSITY OF ARIZONA</span><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:10.0pt;color:#495057"> </span><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:10.0pt;color:#495057">Biological Sciences West, 368<br>
PO Box 210088 | Tucson, AZ 85721<br>
Office: 520-621-6354 <br>
<a href="mailto:mckinleya@arizona.edu">mckinleya@arizona.edu</a></span><o:p></o:p></p>
<p class="xmsonormal"><b><span style="font-size:10.0pt;color:#495057"><a href="https://www.arizona.edu/"><span style="color:#8B0015">www.arizona.edu</span></a></span></b><span style="font-size:10.0pt;color:#495057"><br>
<a href="https://facebook.com/uarizona"><span style="font-size:9.0pt;color:#8B0015">facebook</span></a></span><span style="font-size:9.0pt;color:#767676"> |
</span><span style="font-size:10.0pt;color:#495057"><a href="https://twitter.com/uarizona"><span style="font-size:9.0pt;color:#8B0015">twitter</span></a></span><span style="font-size:9.0pt;color:#767676"> |
</span><span style="font-size:10.0pt;color:#495057"><a href="https://www.instagram.com/uarizona"><span style="font-size:9.0pt;color:#8B0015">instagram</span></a></span><span style="font-size:9.0pt;color:#767676"> |
</span><span style="font-size:10.0pt;color:#495057"><a href="https://www.linkedin.com/school/the-university-of-arizona"><span style="font-size:9.0pt;color:#8B0015">linkedin</span></a>
</span><o:p></o:p></p>
</td>
</tr>
<tr>
<td width="120" style="width:1.25in;padding:0in 0in 0in 0in"></td>
<td width="500" style="width:375.0pt;padding:0in 0in 0in 0in">
<p class="xmsonormal"><a href="https://brand.arizona.edu/signature"><span style="color:blue;text-decoration:none"><img border="0" width="399" height="96" style="width:4.1562in;height:1.0in" id="x_Picture_x0020_2" src="cid:image002.png@01D8E2FC.11044C80" alt="Integrity, Compassion, Exploration, Adaptation, Inclusion, Determination"></span></a><o:p></o:p></p>
</td>
</tr>
</tbody>
</table>
<p class="xmsonormal"> <o:p></o:p></p>
<p class="xmsonormal"> <o:p></o:p></p>
</div>
</div>
</div>
</body>
</html>