[Plantsci] FW: MCB Joint Seminar & Journal Club

Tue Feb 12 09:19:31 MST 2019

From: mcbjointseminar-request at list.arizona.edu <mcbjointseminar-request at list.arizona.edu> On Behalf Of DeGroot, Whitney R - (wslay)
Sent: Tuesday, February 12, 2019 9:14 AM
To: mcbjointseminar at list.arizona.edu
Subject: [mcbjointseminar] MCB Joint Seminar & Journal Club

MCB Faculty Candidate Seminar (Joint Seminar)

Title: Embracing change: somatic plasticity as a strategy for host defense and reproduction
Speaker: Christopher Arnold, HHMI Postdoctoral Research Associate, Stowers Institute
Location/Time: ENR2 Room S107 @ 11AM
Host: Justina McEvoy

Abstract: Somatic tissue turnover is a conserved strategy of preservation through change that is differentially utilized throughout organs and organisms. Study of organisms with a high degree somatic turnover across multiple tissues has the potential to shed light on fundamental mechanisms relevant for our understanding of wound healing, tissue regeneration, chronic inflammatory disorders, and tumorigenesis. The planaria Schmidtea mediterranea, maintains all adult tissues through controlled somatic turnover. Their unrestricted growth, immortality, and regenerative abilities arise from an enduring pool of totipotent adult stem cells that divide and differentiate to replace lost cells during homeostasis and injury. This somatic plasticity underlies the planarians' approach to host defense and asexual reproduction. In response to pathogenic challenge planaria increase their rate of cell turnover via TAK1 pathway mediated cell death and stem cell proliferation. Strategic utilization of somatic tissue is also key to their propagation. Planaria reproduce asexually by physically tearing off a portion of their posterior tissue that will regenerate into clonal progeny. This process requires careful integration of indeterminate growth and behavior mediated by the Wnt and TGF-Beta signaling pathways. Collectively, these attributes position planaria as a uniquely advantageous model for dissecting the regulation of cell turnover, size-dependent pattern formation, and coordinated tissue growth.
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MCB Journal Club

Title: Circuit Design Features of a Stable Two-Cell System
Speakers: Kotaro Fujimaki, Hao Zhang, Angelica Escoto
Location/Day/Time: AME Room S324 **Note room change**
Contact: Ryan Gutenkunst
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Whitney DeGroot |Building Manager
Administrative Associate | Molecular and Cellular Biology
Life Sciences South Room 431 | Tucson, AZ 85721
📞(520) 626-0542 | FAX: (520) 621-3709

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