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<p class="MsoNormal"><b>From:</b> mcbjointseminar-request@list.arizona.edu <mcbjointseminar-request@list.arizona.edu>
<b>On Behalf Of </b>DeGroot, Whitney R - (wslay)<br>
<b>Sent:</b> Tuesday, February 12, 2019 9:14 AM<br>
<b>To:</b> mcbjointseminar@list.arizona.edu<br>
<b>Subject:</b> [mcbjointseminar] MCB Joint Seminar & Journal Club<o:p></o:p></p>
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<p class="MsoNormal"><b>MCB Faculty Candidate Seminar (Joint Seminar)<o:p></o:p></b></p>
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<p class="MsoNormal">Title: Embracing change: somatic plasticity as a strategy for host defense and reproduction<o:p></o:p></p>
<p class="MsoNormal">Speaker: Christopher Arnold, HHMI Postdoctoral Research Associate, Stowers Institute<o:p></o:p></p>
<p class="MsoNormal">Location/Time: ENR2 Room S107 @ 11AM<o:p></o:p></p>
<p class="MsoNormal">Host: Justina McEvoy<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Abstract: <i>Somatic tissue turnover is a conserved strategy of preservation through change that is differentially utilized throughout organs and organisms. Study of organisms with a high degree somatic turnover across multiple tissues
has the potential to shed light on fundamental mechanisms relevant for our understanding of wound healing, tissue regeneration, chronic inflammatory disorders, and tumorigenesis. The planaria Schmidtea mediterranea, maintains all adult tissues through controlled
somatic turnover. Their unrestricted growth, immortality, and regenerative abilities arise from an enduring pool of totipotent adult stem cells that divide and differentiate to replace lost cells during homeostasis and injury. This somatic plasticity underlies
the planarians' approach to host defense and asexual reproduction. In response to pathogenic challenge planaria increase their rate of cell turnover via TAK1 pathway mediated cell death and stem cell proliferation. Strategic utilization of somatic tissue is
also key to their propagation. Planaria reproduce asexually by physically tearing off a portion of their posterior tissue that will regenerate into clonal progeny. This process requires careful integration of indeterminate growth and behavior mediated by the
Wnt and TGF-Beta signaling pathways. Collectively, these attributes position planaria as a uniquely advantageous model for dissecting the regulation of cell turnover, size-dependent pattern formation, and coordinated tissue growth.</i><o:p></o:p></p>
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<p class="MsoNormal"><b>MCB Journal Club<o:p></o:p></b></p>
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<p class="MsoNormal">Title: Circuit Design Features of a Stable Two-Cell System<o:p></o:p></p>
<p class="MsoNormal">Speakers: Kotaro Fujimaki, Hao Zhang, Angelica Escoto<span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal">Location/Day/Time: <span style="color:red">AME Room S324 **Note room change**</span><o:p></o:p></p>
<p class="MsoNormal">Contact: Ryan Gutenkunst<o:p></o:p></p>
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<p class="MsoNormal" style="line-height:105%"><b><span style="font-size:12.0pt;line-height:105%">Whitney DeGroot</span></b> |Building Manager<br>
Administrative Associate | Molecular and Cellular Biology<o:p></o:p></p>
<p class="MsoNormal" style="line-height:105%">Life Sciences South Room 431 | Tucson, AZ 85721<br>
<span style="font-family:"Segoe UI Symbol",sans-serif">📞(</span>520) 626-0542 | FAX: (520) 621-3709<o:p></o:p></p>
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