[Plantsci] RE: BIO5 Distinguished Scholar, Dr. Jeffrey Fredberg, to visit UA Nov. 21

[Lambert, Georgina M - (glambert)]

Subject: BIO5 Distinguished Scholar, Dr. Jeffrey Fredberg, to visit UA Nov. 21

The BIO5 Institute is honored to welcome renowned Harvard professor of bioengineering and physiology, Dr. Jeffrey Fredberg, PhD, to the University of Arizona on Thursday, November 21st for a two-lecture event. Dr. Fredberg's expertise in the evolving mechanistic understanding of physical properties of the living cell may hold the key to major advancements in bioresearch.

8:00AM Check-in & Breakfast

Thomas W. Keating Bioresearch Building, Room 103
8:30-9:30 AM Deep Inspirations, Small Airways, High Throughput
Among all factors known to antagonize bronchoconstriction in a healthy lung, a deep inspiration (DI) is among the most effective. In the asthmatic lung, however, this protective phenomenon is substantially attenuated, and during a spontaneous asthmatic attack it is sometimes even reversed. Some have suggested that the inability of a DI to dilate the constricted asthmatic airway might be an important cause of excessive airway narrowing. To explain these observations, a new conceptual framework calls attention to the role of airway smooth muscle and the dynamic load against which it must contract.  Contracted airway smooth muscle cell becomes refractory to a DI because its cytoskeleton fails to fluidize, and instead remains frozen in a stiff solid-like contracted phase.

RSVP is required for this talk as seating is limited:
BIO5Lectures.arizona.edu<http://bio5lectures.arizona.edu/>

Student Union, Kiva Room
3:00-4:00 PM Toward the Void: Propulsion, Navigation and Jamming within the Advancing Monolayer Sheet
As a wound heals, or a body plan forms, or a tumor invades, observed cellular motions within the advancing cell swarm are thought to stem from yet to be observed physical stresses that act in some direct and causal mechanical fashion. Here we show that such a relationship between motion and stress is far from direct. Using monolayer stress microscopy, we probed migration velocities, cellular tractions and intercellular stresses in an epithelial cell sheet advancing towards an island on which cells cannot adhere. We found that cells located near the island exert tractions that pull systematically towards this island regardless of whether the cells approach the island, migrate tangentially along its edge, or paradoxically, recede from it. This unanticipated cell-patterning motif, which we call kenotaxis, represents the robust and systematic mechanical drive of the cellular collective to fill unfilled space.

Live streaming of this talk will also take place in the Thomas W. Keating Bioresearch Building, Room 103

For more information and to RSVP, visit: BIO5Lectures.arizona.edu<http://bio5lectures.arizona.edu/> or see attached flyer.

Contact: Amy Randall at amyrandall at bio5.org<mailto:amyrandall at bio5.org> (520)626-3001<tel:%28520%29626-3001> or Heather Ingram hci at bio5.org<mailto:hci at bio5.org> (520)621-1773<tel:%28520%29621-1773>
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