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<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">Subject:</span></b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif""> BIO5 Distinguished Scholar, Dr. Jeffrey Fredberg, to visit UA Nov. 21<o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">The BIO5 Institute</span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""> is honored to welcome renowned Harvard professor of bioengineering and physiology, <b>Dr.
Jeffrey Fredberg, PhD</b>, to the University of Arizona on <b>Thursday, November 21st</b> for a two-lecture event. Dr. Fredberg’s expertise in the evolving mechanistic understanding of physical properties of the living cell may hold the key to major advancements
in bioresearch.<o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">8:00AM Check-in & Breakfast</span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Thomas W. Keating Bioresearch Building, Room 103</span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">8:30-9:30 AM Deep Inspirations, Small Airways, High Throughput</span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Among all factors known to antagonize bronchoconstriction in a healthy lung, a deep inspiration (DI) is among the most effective. In the asthmatic lung, however, this protective
phenomenon is substantially attenuated, and during a spontaneous asthmatic attack it is sometimes even reversed. Some have suggested that the inability of a DI to dilate the constricted asthmatic airway might be an important cause of excessive airway narrowing.
To explain these observations, a new conceptual framework calls attention to the role of airway smooth muscle and the dynamic load against which it must contract. Contracted airway smooth muscle cell becomes refractory to a DI because its cytoskeleton fails
to fluidize, and instead remains frozen in a stiff solid-like contracted phase.<o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">RSVP is required for this talk as seating is limited: </span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><a href="http://bio5lectures.arizona.edu/" target="_blank">BIO5Lectures.arizona.edu</a></span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Student Union, Kiva Room</span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""> <o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">3:00-4:00 PM Toward the Void: Propulsion, Navigation and Jamming within the Advancing Monolayer Sheet</span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">As a wound heals, or a body plan forms, or a tumor invades, observed cellular motions within the advancing cell swarm are thought to stem from yet to be observed physical stresses
that act in some direct and causal mechanical fashion. Here we show that such a relationship between motion and stress is far from direct. Using monolayer stress microscopy, we probed migration velocities, cellular tractions and intercellular stresses in an
epithelial cell sheet advancing towards an island on which cells cannot adhere. We found that cells located near the island exert tractions that pull systematically towards this island regardless of whether the cells approach the island, migrate tangentially
along its edge, or paradoxically, recede from it. This unanticipated cell-patterning motif, which we call kenotaxis, represents the robust and systematic mechanical drive of the cellular collective to fill unfilled space.<o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Live streaming of this talk will also take place in the Thomas W. Keating Bioresearch Building, Room 103</span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">For more information and to RSVP, visit: <a href="http://bio5lectures.arizona.edu/" target="_blank">BIO5Lectures.arizona.edu</a> or see attached flyer. </span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Contact: Amy Randall at <a href="mailto:amyrandall@bio5.org" target="_blank">amyrandall@bio5.org</a> <a href="tel:%28520%29626-3001" target="_blank">(520)626-3001</a> or
Heather Ingram <a href="mailto:hci@bio5.org" target="_blank">hci@bio5.org</a> <a href="tel:%28520%29621-1773" target="_blank">(520)621-1773</a></span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p></o:p></span></p>
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