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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> Ibarra, Daniela - (dcastro) [mailto:dcastro@email.arizona.edu] <br><b>Sent:</b> Thursday, February 23, 2012 4:47 PM<br><b>To:</b> Sonnenberg, Kerrie M - (kerrie); georgina@ag.arizona.edu<br><b>Subject:</b> Please send to listserv: ABE Seminar - Kyung-Jin Jang, Harvard University<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal align=center style='text-align:center'><img width=191 height=195 id="Picture_x0020_2" src="cid:image003.jpg@01CCF247.68EFFD60"><o:p></o:p></p><p class=MsoNormal align=center style='text-align:center'><strong><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></strong></p><p class=MsoNormal align=center style='text-align:center'><strong><span style='font-size:13.5pt'>Department of Agricultural and Bio-systems Engineering </span></strong><o:p></o:p></p><p class=MsoNormal align=center style='text-align:center'><strong><span style='font-size:13.5pt'>Graduate Seminar-ABE 696</span></strong>a<o:p></o:p></p><div><p class=MsoNormal><o:p> </o:p></p></div><div><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center'><b><span style='font-size:13.5pt;font-family:"Calibri","sans-serif"'>"<i><span style='color:black'> In vivo</span></i><span style='color:black'>-like microenvironments for renal tubular cells and</span></span></b><o:p></o:p></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center'><b><span style='font-size:13.5pt;font-family:"Calibri","sans-serif";color:black'>guided neurite outgrowth </span></b><b><span style='font-size:13.5pt;font-family:"Calibri","sans-serif"'>”</span></b><o:p></o:p></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center;text-autospace:none'><b><span style='font-family:"Tahoma","sans-serif"'> </span></b><o:p></o:p></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center;text-autospace:none'><b><span style='font-family:"Tahoma","sans-serif"'>Abstract:</span></b><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><i><span style='font-family:"Georgia","serif"'> </span></i><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><i><span style='font-family:"Georgia","serif"'>In vivo</span></i><span style='font-family:"Georgia","serif"'>, cells respond to surrounding mechanical/chemical stimulations and complex three-dimensional anisotropic environments. To understand these mechanisms, cells need to be maintained in an <i>in vivo</i>-like environment that reproduces key structural, functional, and mechanical properties of the target organ. In this talk, I will describe two biomimetic microsystem that reconstitutes critical functional aspects of the renal and nervous system. To emulate the kidney tubular environment, microfluidic-based techniques were used to recapitulate the complexity of the renal microenvironment <i>in vitro</i>, including fluid shear stress and transepithelial chemical gradient. The device included the integration of a polydimethyl siloxane (PDMS) microfluidic channel to generate fluid shear stress, a porous membrane, and a PDMS reservoir. Culture of renal tubule cells in the microfluidic device under fluid shear stress resulted in enhanced cell polarization, cytoskeletal reorganization, and cilia formation. In addition, to study the complex morphogenetic event of neurite outgrowth, we used UV-assisted capillary force lithography with polyurethane acrylate to construct different topographic patterns. These nanotopographical patterns can provide an insight into how neuronal growth cones can sense geometric ECM cues, which possibly leads to new applications in tissue regeneration after nerve injury as well as the treatment of neuropathological conditions. We also have on-going work on human kidney proximal tubule-on-a-chip for more predictive <i>in vitro</i> human kidney models for investigating absorption, distribution, metabolism, excretion, and toxicological properties of new chemical entities during the drug development process. This novel system may also provide a useful and cost-effective tool for studying biotransformation profiles, renal pharmacology, renal drug transport and toxicity relevant to the human kidney, and hence help to facilitate the drug development process with a more human-relevant model.</span><o:p></o:p></p></div><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center;text-autospace:none'><b><span style='font-size:13.5pt;font-family:"Calibri","sans-serif"'>Kyung-Jin Jang, PhD</span></b><o:p></o:p></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center;text-autospace:none'><b><span style='font-family:"Calibri","sans-serif"'>Wyss Institute for Biologically Inspired Engineering, Harvard University</span></b><o:p></o:p></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center;text-autospace:none'><span style='font-family:"Calibri","sans-serif"'> </span><o:p></o:p></p><h2 align=center style='text-align:center;text-autospace:ideograph-other'><span style='font-size:13.5pt;font-family:"Arial","sans-serif"'>Monday, February 27, 2012</span><o:p></o:p></h2><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center'><b><span style='font-size:13.5pt;font-family:"Arial","sans-serif"'>12:00 P.M. - 1:00 P.M.</span></b><o:p></o:p></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center'><b><span style='font-size:13.5pt;font-family:"Arial","sans-serif"'>Shantz 440</span></b><o:p></o:p></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center'><b><span style='font-size:16.0pt;font-family:"Garamond","serif"'> </span></b><o:p></o:p></p></div></body></html>