[Plsfaculty] FW: NIH Directors Opportunity for Research in Five Thematic Areas (RC4)

[Donna-Rae Marquez]

From: Matthew Nelson [mailto:MNelson at flinn.org] 
Sent: Monday, January 04, 2010 10:18 AM
Subject: NIH Directors Opportunity for Research in Five Thematic Areas (RC4)

 

Scope. This grants program is aimed at research endeavors that address one
or more of the following five thematic areas:

1.       Applying Genomics and Other High Throughput Technologies:  In the
past, many basic biomedical science projects were limited in scope to some
aspect of genetics, cell biology, or physiology.  The revolution now
sweeping the field is the ability to be comprehensive - for example, to
define all of the genes of the human, model organisms or the human
microbiota, all of the human proteins and their structures, or all of the
major pathways for signal transduction in the cell. Technologies
contributing to these advances, many of which became practical at scale only
in the last few years, include DNA sequencing, microarray technology,
nanotechnology, small molecule screening capabilities, new imaging
modalities, and computational biology.  These comprehensive approaches
coupled with systems-level integration, analysis and mining of large
datasets now hold the promise of major advances in the understanding of the
mechanisms of diseases.  

2.       Translating Basic Science Discoveries into New and Better
Treatments:  Armed with a wealth of basic science discoveries and an
understanding of the pathophysiology of various diseases, we are embarking
on the next frontier in designing new diagnostic and therapeutic strategies.
Molecular and cellular insights into a disease can be developed into
screening assays on hundreds of thousands of compounds, and tested in
disease models to identify the most promising leads that can sustain the
drug development pipeline and attract public-private partnerships for
further pursuits. Additional pathways to therapeutics from gene therapy,
biologics, and stem cells (including iPS cells) are also showing great
promise. The opportunity is here for translational science to develop small
molecule-based, gene-based, protein/peptide-based and cell-based therapies
for common as well as rare diseases.  

3.       Using Science to Enable Health Care Reform:  Quality, affordable
health care for all Americans cannot occur without significant advances in
the underlying science that will enable effective and efficient disease
prevention and diagnosis, as well as better and cheaper treatments to be
identified.  Clinical research targeted toward health disparities, social
and behavioral factors, large-scale prospective population cohort analysis,
comparative effectiveness, cost-effective prevention and personalized
medicine, and pharmacogenomics will allow us to assess and mitigate disease
risks, predict outcome and optimize treatment.  Health services research
that includes health information technology and health research economics
will enhance the safety, quality and efficiency of the health care delivery
system, as well as facilitate health promotion.

4.       Focusing on Global Health:  The NIH has a long tradition of
supporting the discovery phase of solutions to major global health
challenges, and recent scientific advances in genomics, small molecule
screening technologies, and vaccine development portend the possibility of
further major impacts on some of the most challenging and harmful diseases
worldwide.  This theme encourages a greater focus on global health and new
emphasis on formulating prevention and intervention strategies to tackle a
number of infectious and parasitic diseases, chronic non-communicable
diseases and injuries, and other neglected diseases striking the developing
world, with the goal to reduce morbidity and mortality associated with these
diseases worldwide.

5.       Reinvigorating the Biomedical Research Community:  The lifeblood of
biomedical research in the United States rests upon the talent and
dedication of its scientists and the support of innovative research.  This
theme encourages investigators to cultivate new collaborations and to
assemble multidisciplinary or interdisciplinary teams in conducting
innovative research on the most challenging biomedical and behavioral areas.
The goal is to strengthen our research capacity, to broaden our research
base and to enhance cross-fertilization of disciplines by recruiting new
investigators and new expertise into the research community, and by
developing and retaining these talents in a collaborative environment that
fosters creativity and exploration.  

 

 

Recovery Act Limited Competition: NIH Directors Opportunity for Research in
Five Thematic Areas (RC4)
(RFA-OD-10-005)
National Institutes of Health
John E. Fogarty International Center
National Center for Complementary and Alternative Medicine
National Cancer Institute
National Center for Minority Health and Health Disparities
National Center for Research Resources
National Eye Institute
National Human Genome Research Institute
National Heart, Lung, and Blood Institute
National Institute on Aging
National Institute on Alcohol Abuse and Alcoholism
National Institute of Allergy and Infectious Diseases
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Institute of Biomedical Imaging and Bioengineering
Eunice Kennedy Shriver National Institute of Child Health and Human
Development 
National Institute on Drug Abuse
National Institute on Deafness and Other Communication Disorders
National Institute of Dental and Craniofacial Research
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Environmental Health Sciences
National Institute of General Medical Sciences
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke
National Institute of Nursing Research
National Library of Medicine
American Reinvestment and Recovery Act of 2009
Application Receipt Date(s): March 15, 2010 
http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-10-005.html

 

Matthew Nelson, MBA

Assistant Vice President

Research Programs

The Flinn Foundation

1802 N. Central Ave

Phoenix AZ 85004-1506

Office: (602) 744 6839

Mobile: (602) 459 6613

Fax: (602) 744 6815

Email: mnelson at flinn.org

http://www.flinn.org/bio-briefs/topic/research

 <http://www.flinn.org/bio-briefs/topic/Research>  

 <http://azbioscientist.blogspot.com>  

 <http://www.azbioscientist2.blogspot.com>  

 

 

 

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